Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CCNK | O75909 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1558150 | 1.00 | CA2 (0.40) | CA2HPGDSLTA4HCCNCCDK8 | |
| SCHEMBL14988353 | 0.77 | HPGDS (0.40) | CA2HPGDSLTA4HCCNCCDK8 | |
| SCHEMBL30753608 | 0.77 | HPGDS (0.40) | CA2HPGDSLTA4HCCNCCDK8 | |
| SCHEMBL13114689 | 0.77 | CCR1 (0.56) | HPGDSLTA4HCCNCCDK8KDM4E | |
| SCHEMBL7429910 | 0.77 | HPGDS (0.40) | HPGDSLTA4HCCNCCDK8GRM5 | |
| SCHEMBL31255994 | 0.77 | HPGDS (0.40) | HPGDSLTA4HCCNCCDK8GRM5 | |
| SCHEMBL1169590 | 0.74 | LTA4H (0.55) | HPGDSLTA4HKDM4EALDH1A1 | |
| SCHEMBL40864 | 0.73 | KDM4E (0.46) | CA2KDM4EALDH1A1SPRADRA2A | |
| SCHEMBL12924082 | 0.73 | LTA4H (0.42) | HPGDSLTA4HGRM5CASP3 | |
| SCHEMBL14211873 | 0.73 | HPGDS (0.37) | HPGDSLTA4HCCNCCDK8BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114853730-B | Compounds used as HPK1 kinase inhibitor, preparation method and application thereof | 中国药科大学 | 2024-03-26 | — | — | CN | disclosed |
| CN-114853730-A | Compound used as HPK1 kinase inhibitor and preparation method and application thereof | 中国药科大学 | 2022-08-05 | — | — | CN | disclosed |