Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 9/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31255994 | 1.00 | HPGDS (0.40) | HPGDSGRM5MAPK14TGFBR1ADRA1A | |
| Formic Acid Methyl Ester SCHEMBL31165950 | 0.86 | TUBB4A (0.34) | HPGDSGRM5ADRA1ALTA4HCCNC | |
| SCHEMBL29843360 | 0.77 | CA2 (0.40) | HPGDSGRM5LTA4HADRA2ACCNC | |
| SCHEMBL13114689 | 0.77 | CCR1 (0.56) | HPGDSGRM5LTA4HCCNCCDK8 | |
| SCHEMBL1558150 | 0.77 | CA2 (0.40) | HPGDSGRM5LTA4HADRA2ACCNC | |
| SCHEMBL30753608 | 0.77 | HPGDS (0.40) | HPGDSLTA4HADRA2ACCNCCDK8 | |
| SCHEMBL14988353 | 0.77 | HPGDS (0.40) | HPGDSLTA4HADRA2ACCNCCDK8 | |
| SCHEMBL12578887 | 0.74 | LTA4H (0.55) | HPGDSMAPK14ADRA1ALTA4HMAPT | |
| SCHEMBL811754 | 0.73 | GRM5 (0.47) | GRM5MAPK14TGFBR1MAPTCYP1A2 | |
| SCHEMBL13222352 | 0.73 | NPSR1 (0.37) | HPGDSLTA4HMAPTCCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002068417-A3 | HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | SLASSI ABDELMALIK (CA) | 2002-11-14 | — | — | WO | disclosed |