Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 3/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 7/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23216905 | 1.00 | C5AR1 (0.36) | C5AR1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL25616566 | 0.87 | CHRM1 (0.44) | OPRM1OPRK1OPRL1DRD2DRD4 | |
| SCHEMBL29844326 | 0.86 | TSHR (0.38) | C5AR1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL23216978 | 0.86 | TSHR (0.38) | C5AR1OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL23216993 | 0.78 | ALDH1A1 (0.40) | C5AR1OPRM1ALDH1A1LMNATNKS | |
| SCHEMBL28076562 | 0.77 | CALCRL (0.40) | OPRM1OPRK1OPRL1DRD2DRD4 | |
| SCHEMBL28076558 | 0.77 | CALCRL (0.40) | OPRM1OPRK1OPRL1DRD2DRD4 | |
| SCHEMBL28233724 | 0.76 | BTK (0.37) | OPRM1OPRK1OPRL1DRD2DRD4 | |
| SCHEMBL29471042 | 0.74 | OPRM1 (0.46) | OPRM1OPRK1DRD2DRD4DRD3 | |
| SCHEMBL25226857 | 0.72 | CHRM2 (0.41) | OPRM1OPRK1OPRL1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041401-A1 | HCK AS A THERAPEUTIC TARGET IN MYD88 MUTATED DISEASES | Dana-Farber Cancer Institute, Inc. (US) | 2022-08-17 | — | — | EP | disclosed |