Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.44 |
| ▸ | PLK4 | O00444 | 6/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | CIT | O14578 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | BUB1 | O43683 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16515085 | 1.00 | JAK2 (0.44) | JAK2PLK4AXLTP53MAPT | |
| SCHEMBL16514000 | 0.91 | AIMP2 (0.40) | JAK2AXLCCNT1EGFRCDK4 | |
| SCHEMBL29847728 | 0.91 | AIMP2 (0.40) | JAK2AXLCCNT1EGFRCDK4 | |
| SCHEMBL29847539 | 0.90 | BACE1 (0.47) | JAK2PLK4AXLJAK3SRC | |
| SCHEMBL16514114 | 0.90 | BACE1 (0.47) | JAK2PLK4AXLJAK3SRC | |
| SCHEMBL16513949 | 0.89 | ERBB3 (0.42) | JAK2PLK4AXLTP53MAPT | |
| SCHEMBL18393372 | 0.89 | ITK (0.45) | JAK2PLK4TP53MAPTMAPK1 | |
| SCHEMBL16513845 | 0.89 | JAK2 (0.42) | JAK2PLK4AXLTP53MAPT | |
| SCHEMBL28388501 | 0.88 | TGFBR1 (0.40) | EPHB4CCNT1TGFBR1CDK9MKNK2 | |
| SCHEMBL16515135 | 0.87 | SRC (0.43) | JAK2AXLTP53MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109851617-B | Chemical entities, compositions, and methods | 润新生物公司 | 2022-08-16 | — | — | CN | disclosed |