Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Codeine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 8/20 | 0.73 |
| ▸ | OPRK1 known ✓ | P41145 | 6/20 | 0.73 |
| ▸ | OPRD1 known ✓ | P41143 | 6/20 | 0.73 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.73 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.73 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.73 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.59 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeine SCHEMBL218798 | 1.00 | OPRM1 (0.73) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 | |
| Codeine SCHEMBL4060875 | 1.00 | OPRM1 (0.73) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 | |
| Codeine SCHEMBL29511777 | 1.00 | OPRM1 (0.73) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 | |
| Codeine SCHEMBL2525939 | 0.98 | OPRM1 (0.77) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 | |
| Acetaminophen SCHEMBL4060870 | 0.90 | OPRM1 (0.66) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 | |
| Morphine SCHEMBL27949569 | 0.89 | OPRM1 (0.73) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 | |
| Codeine SCHEMBL24578 | 0.89 | OPRD1 (0.93) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 | |
| Codeine SCHEMBL24580 | 0.89 | OPRD1 (0.93) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 | |
| Codeine SCHEMBL11057867 | 0.89 | OPRM1 (0.63) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 | |
| Codeine SCHEMBL29409567 | 0.88 | OPRM1 (0.93) | OPRM1OPRK1OPRD1MRGPRX2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4547280-A1 | BIOPOLYMER FORMULATIONS FOR DRUG DELIVERY | 11584022 Canada Inc. (CA) | 2025-05-07 | — | — | EP | claimed |
| WO-2024003790-A1 | BIOPOLYMER FORMULATIONS FOR DRUG DELIVERY | 11584022 CANADA INC. (CA) | 2024-01-04 | — | — | WO | claimed |
| EP-4655310-A2 | METHODS AND COMPOSITIONS FOR COMBINATION THERAPY | Simcha Il-18, Inc. (US) | 2025-12-03 | — | — | EP | disclosed |
| EP-4630821-A2 | BIOMARKER-BASED SYSTEMS AND METHODS OF DRUG IMPACT ASSESSMENT FOR USE IN PERSONALISED HEALTHCARE | Randox Laboratories Ltd (GB) | 2025-10-15 | — | — | EP | disclosed |
| EP-4547280-A1 | BIOPOLYMER FORMULATIONS FOR DRUG DELIVERY | 11584022 Canada Inc. (CA) | 2025-05-07 | — | — | EP | disclosed |
| WO-2025064547-A1 | MACHINE LEARNING CLASSIFICATION OF SOLID TUMORS BASED ON GENE EXPRESSION | AMPEL BIOSOLUTIONS, LLP (US) | 2025-03-27 | — | — | WO | disclosed |
| EP-4408314-A2 | SKIN TREATMENT SYSTEMS, DEVICES, AND METHODS | Cytrellis Biosystems, Inc. (US) | 2024-08-07 | — | — | EP | disclosed |
| WO-2024158838-A2 | METHODS AND COMPOSITIONS FOR COMBINATION THERAPY | Simcha IL-18, Inc. (US) | 2024-08-02 | — | — | WO | disclosed |
| WO-2024121285-A2 | BIOMARKER-BASED SYSTEMS AND METHODS OF DRUG IMPACT ASSESSMENT FOR USE IN PERSONALISED HEALTHCARE | RANDOX LABORATORIES LTD (GB) | 2024-06-13 | — | — | WO | disclosed |
| CN-117897138-A | Treatment of respiratory disorders | 海波流动有限公司 | 2024-04-16 | — | — | CN | disclosed |
| EP-4307961-A2 | METHOD AND DEVICE FOR TREATING THE SKIN | Venus Concept Inc. (CA) | 2024-01-24 | — | — | EP | disclosed |
| WO-2024003790-A1 | BIOPOLYMER FORMULATIONS FOR DRUG DELIVERY | 11584022 CANADA INC. (CA) | 2024-01-04 | — | — | WO | disclosed |
| WO-2023238041-A1 | METHOD AND DEVICE FOR TREATING CELLULITE | VENUS CONCEPT INC. (CA) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023238038-A1 | METHOD AND DEVICE FOR TREATING CELLULITE | VENUS CONCEPT INC. (CA) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023238040-A1 | METHOD AND DEVICE FOR TREATING CELLULITE | VENUS CONCEPT INC. (CA) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023049500-A2 | SKIN TREATMENT SYSTEMS, DEVICES, AND METHODS | CYTRELLIS BIOSYSTEMS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |
| CN-109311929-B | SECO macrolide compounds | 塞尔维塔公司 | 2022-10-04 | — | — | CN | disclosed |
| WO-2022197674-A2 | METHOD AND DEVICE FOR TREATING THE SKIN | VENUS CONCEPT INC. (CA) | 2022-09-22 | — | — | WO | disclosed |