Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Codeine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 7/20 | 0.93 |
| ▸ | OPRD1 known ✓ | P41143 | 8/20 | 0.91 |
| ▸ | OPRK1 known ✓ | P41145 | 5/20 | 0.91 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.91 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.91 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.91 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.91 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.69 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeine SCHEMBL1275480 | 1.00 | OPRM1 (0.93) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL2515523 | 1.00 | OPRM1 (0.93) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL24578 | 0.99 | OPRD1 (0.93) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL24580 | 0.99 | OPRD1 (0.93) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL3031563 | 0.96 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL29938690 | 0.96 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL7632902 | 0.96 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL7936660 | 0.95 | OPRD1 (0.86) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL9324126 | 0.95 | OPRM1 (0.98) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL1560699 | 0.95 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4544569-A1 | DEVICE AND METHOD FOR INTERACTIVELY PERFORMING SAMPLING AND/OR DISINFECTION | Fresenius Medical Care Deutschland GmbH (DE) | 2025-04-30 | — | — | EP | claimed |
| EP-4107583-A1 | PARTICLE TEST SYSTEM, SAMPLING TAPE, PROJECTION EXPOSURE APPARATUS AND METHOD FOR TESTING PARTICLE CONTAMINATION ON A SURFACE | Carl Zeiss SMT GmbH (DE) | 2022-12-28 | — | — | EP | claimed |
| EP-4742889-A1 | METHODS FOR ANTIBODY PRODUCTION | Hummingbird Bioscience Pte. Ltd. (SG) | 2026-05-20 | — | — | EP | disclosed |
| EP-4742890-A1 | METHODS FOR ANTIBODY PRODUCTION | Hummingbird Bioscience Pte. Ltd. (SG) | 2026-05-20 | — | — | EP | disclosed |
| CN-122055054-A | Antibody production method | 蜂鸟生物科技私人有限公司 | 2026-05-15 | — | — | CN | disclosed |
| US-20250353927-A1 | SERINE PROTEASE INHIBITOR KAZAL (SPIK) COMPOSITIONS AND METHODS | IMCARE BIOTECH LLC (US) | 2025-11-20 | — | — | US | disclosed |
| US-12377162-B2 | Anti-serine protease inhibitor kazal (SPIK) antibodies, immunoconjugates, and methods of use | IMCARE BIOTECH, LLC (US) | 2025-08-05 | — | — | US | disclosed |
| CN-120005029-A | Serine protease inhibitor Kazal (spike) compositions and methods | 英凯尔生物科技有限责任公司 | 2025-05-16 | — | — | CN | disclosed |
| EP-4544569-A1 | DEVICE AND METHOD FOR INTERACTIVELY PERFORMING SAMPLING AND/OR DISINFECTION | Fresenius Medical Care Deutschland GmbH (DE) | 2025-04-30 | — | — | EP | disclosed |
| CN-119874926-A | Anti-serine protease inhibitor KAZAL (spike) antibodies, immunoconjugates and methods of use | 英凯尔生物科技有限责任公司 | 2025-04-25 | — | — | CN | disclosed |
| CN-119351412-A | Gene DG1C01667.1 related to plant flowering time and application thereof | 四川农业大学 | 2025-01-24 | — | — | CN | disclosed |
| CN-114901699-A | Epitopes of anti-Serine Protease Inhibitor KAZAL (SPIK) antibodies | 英凯尔生物科技有限责任公司 | 2022-08-12 | — | — | CN | disclosed |
| EP-4028043-A1 | AN IMMUNOTHERAPEUTIC FOR PROSTATE CANCER TREATMENT | Hexamer Therapeutics, Inc. (US) | 2022-07-20 | — | — | EP | disclosed |
| CN-114599387-A | Immunotherapeutic agent for treating prostate cancer | 海克斯麦治疗公司 | 2022-06-07 | — | — | CN | disclosed |
| EP-4003448-A1 | DEVICE FOR PROVIDING DIALYSIS CONCENTRATE | Fresenius Medical Care GmbH (DE) | 2022-06-01 | — | — | EP | disclosed |
| EP-3996816-A1 | ANTI-SERINE PROTEASE INHIBITOR KAZAL (SPIK) ANTIBODIES, IMMUNOCONJUGATES, AND METHODS OF USE | Imcare Biotech, LLC (US) | 2022-05-18 | — | — | EP | disclosed |
| EP-3984376-A1 | LACTASE FOR USE | Nukamel NV (BE) | 2022-04-20 | — | — | EP | disclosed |
| EP-3984375-A1 | USE OF A LOW-LACTOSE DAIRY-BASED MILK REPLACER FOR BOVINES | Nukamel NV (BE) | 2022-04-20 | — | — | EP | disclosed |
| CN-114174341-A | anti-Serine Protease Inhibitor KAZAL (SPIK) antibodies, immunoconjugates and methods of use | 英凯尔生物科技有限责任公司 | 2022-03-11 | — | — | CN | disclosed |
| WO-2022047243-A1 | METHODS AND COMPOSITIONS TO TREAT AUTOIMMUNE DISEASES AND CANCER | ENOSI LIFE SCIENCES CORP. (US) | 2022-03-03 | — | — | WO | disclosed |