Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Codeine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 known ✓ | P41143 | 8/20 | 0.93 |
| ▸ | OPRM1 known ✓ | P35372 | 7/20 | 0.93 |
| ▸ | OPRK1 known ✓ | P41145 | 5/20 | 0.93 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.93 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.93 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.93 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.93 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.71 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.71 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeine SCHEMBL24578 | 1.00 | OPRD1 (0.93) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL28121143 | 0.99 | OPRD1 (0.91) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL1275480 | 0.99 | OPRM1 (0.93) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL2515523 | 0.99 | OPRM1 (0.93) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL29409567 | 0.99 | OPRM1 (0.93) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL7936660 | 0.96 | OPRD1 (0.86) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL1560699 | 0.96 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL14371354 | 0.96 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL3257 | 0.96 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL21077535 | 0.96 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 11233 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119700879-A | Antidepressant composition containing compound licorice tablets and application thereof | 广州粤华制药有限公司 | 2025-03-28 | — | — | CN | claimed |
| WO-2024239008-A1 | TRIACIN-C PRODUCT | STI PHARMA, LLC (US) | 2024-11-21 | — | — | WO | claimed |
| US-12145951-B2 | Inorganic-organic hybrid compounds including organic platinum-containing anions, for use in medicine | KARLSRUHER INSTITUT FUR TECHNOLOGIE (DE) | 2024-11-19 | — | — | US | claimed |
| CN-118671254-A | Construction method of loquat cough relieving capsule fingerprint | 河北省药品医疗器械检验研究院(河北省化妆品检验研究中心) | 2024-09-20 | — | — | CN | claimed |
| US-20240299292-A1 | STABLE SEMI-SOLID CHEWABLE GEL COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF | SEATTLE GUMMY COMPANY (US) | 2024-09-12 | — | — | US | claimed |
| EP-3863708-B1 | MIXED IONIC CONDUCTORS AND CORRESPONDING DEVICES, SYSTEMS AND METHODS OF MAKING | BATTELLE MEMORIAL INSTITUTE (US) | 2024-09-11 | — | — | EP | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| US-12064400-B1 | Method and system for reducing active ingredient potency in pain-management compositions to a quarter amount of approved levels | Luduss, LLC (US) | 2024-08-20 | — | — | US | claimed |
| EP-3641774-B1 | PECTIN GUMMY COMPOSITION AND METHODS OF MAKING AND USING THEREOF | SEATTLE GUMMY COMPANY (US) | 2024-03-27 | — | — | EP | claimed |
| EP-4327797-A2 | MULTI PHASE SOFT GEL CAPSULES, APPARATUS AND METHOD THEREOF | Catalent Ontario Limited (CA) | 2024-02-28 | — | — | EP | claimed |
| EP-0114886-A1 | IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE. | SUNSHINE ABRAHAM (US) | 1984-08-08 | — | — | EP | claimed |
| US-4443428-A | PARAFFIN WAXES, ALCOHOLS, FREE BASE AND SALT MIXTURES | EUROCELTIQUE, S.A. (LU) | 1984-04-17 | — | — | US | claimed |
| WO-1984000490-A1 | IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE AND METHODS OF USING SAME | SUNSHINE ABRAHAM | 1984-02-16 | — | — | WO | claimed |
| WO-1984000488-A1 | IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE AND METHODS OF USING SAME | RICHARDSON VICKS INC (US) | 1984-02-16 | — | — | WO | claimed |
| US-4369172-A | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose | FOREST LABORATORIES INC. (US) | 1983-01-18 | — | — | US | claimed |
| EP-0009423-B1 | HYDROPHOBIC SUBSTRATE CAPABLE OF LIBERATING A CHEMICAL COMPOUND, PROCESS FOR ITS PREPARATION AND ITS APPLICATION AS AN INTRA-UTERINE DEVICE | COMMISSARIAT A L'ENERGIE ATOMIQUE Etablissement de Caractère Scientifique Technique et Industriel (FR) | 1982-05-05 | — | — | EP | claimed |
| EP-0040472-A2 | Spray dried N-acetyl-p-aminophenol compositions and method for manufacture thereof | Mallinckrodt, Inc. (a Delaware corporation) (US) | 1981-11-25 | — | — | EP | claimed |
| US-4283325-A | INCLUSIONS OF POLYMERIZED COMPOUNDS IN A POLYMER MATRIX | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 1981-08-11 | — | — | US | claimed |
| US-4181719-A | Analgesic N-acetyl-para-aminophenyl N'-acetylaminothioalkanoates | STERLING DRUG INC. (US) | 1980-01-01 | — | — | US | claimed |
| US-4126684-A | 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE | CIBA-GEIGY CORPORATION (US) | 1978-11-21 | — | — | US | claimed |