Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Oxfenicine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | GRM8 | O00222 | 2/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | GRM6 | O15303 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxfenicine SCHEMBL652186 | 0.92 | HSD17B10 (0.55) | SRCHSD17B10ALDH1A1HPGDKDM4E | |
| Oxfenicine SCHEMBL124861 | 0.92 | HSD17B10 (0.55) | SRCHSD17B10ALDH1A1HPGDKDM4E | |
| Oxfenicine SCHEMBL122315 | 0.92 | HSD17B10 (0.55) | SRCHSD17B10ALDH1A1HPGDKDM4E | |
| Oxfenicine SCHEMBL3492041 | 0.90 | TDP1 (0.53) | SRCHSD17B10ALDH1A1HPGDKDM4E | |
| Oxfenicine SCHEMBL3500341 | 0.90 | TDP1 (0.53) | SRCHSD17B10ALDH1A1HPGDKDM4E | |
| Oxfenicine SCHEMBL3492039 | 0.90 | TDP1 (0.53) | SRCHSD17B10ALDH1A1HPGDKDM4E | |
| Oxfenicine SCHEMBL28362139 | 0.88 | TDP1 (0.52) | SRCHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL13527786 | 0.82 | HSD17B10 (0.61) | SRCHSD17B10ALDH1A1HPGDKDM4E | |
| Oxfenicine SCHEMBL23405810 | 0.82 | LMNA (0.50) | SRCHSD17B10ALDH1A1HPGDKDM4E | |
| Oxfenicine SCHEMBL31259364 | 0.82 | LMNA (0.50) | SRCHSD17B10ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110467537-B | Preparation process of L-p-hydroxyphenylglycine | 河南新天地药业股份有限公司 | 2022-10-04 | — | — | CN | disclosed |