Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CLK3 | P49761 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1538274 | 1.00 | NAMPT (0.51) | NAMPTNPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL28091184 | 0.88 | NPC1 (0.46) | NAMPTNPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL507242 | 0.87 | RAB9A (0.66) | NPC1RAB9AL3MBTL1KDM4ETDP1 | |
| SCHEMBL31266420 | 0.83 | SMN1; SMN2 (0.51) | NPC1RAB9AL3MBTL1KDM4ETDP1 | |
| SCHEMBL260218 | 0.83 | SMN1; SMN2 (0.51) | NPC1RAB9AL3MBTL1KDM4ETDP1 | |
| SCHEMBL8861663 | 0.81 | NPC1 (0.53) | NAMPTNPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL5279767 | 0.81 | NAMPT (0.46) | NAMPTNPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL17546404 | 0.81 | THRB (0.59) | NAMPTNPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL30147616 | 0.81 | THRB (0.59) | NAMPTNPC1RAB9AL3MBTL1KDM4E | |
| SCHEMBL17540483 | 0.80 | TAS1R3 (0.55) | NAMPTNPC1RAB9AL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118076602-A | Heteroaryl-acetylenes, pharmaceutical compositions thereof and their therapeutic uses | 嘉兴优博生物技术有限公司 | 2024-05-24 | — | — | CN | claimed |
| CN-118401502-A | Benzothiazole, benzisoxazole and benzodioxole analogs as RXFP1 receptor agonists | 百时美施贵宝公司 | 2024-07-26 | — | — | CN | disclosed |
| CN-118076602-A | Heteroaryl-acetylenes, pharmaceutical compositions thereof and their therapeutic uses | 嘉兴优博生物技术有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-116867758-A | IRAK degradation agents and uses thereof | 凯麦拉医疗公司 | 2023-10-10 | — | — | CN | disclosed |
| CN-116133692-A | Methods of treating mutant lymphomas | 凯麦拉医疗公司 | 2023-05-16 | — | — | CN | disclosed |
| CN-109843879-B | Benzothiazole derivatives as DYRK1 inhibitors | 药物治疗股份有限公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-115052627-A | IRAK degrading agents and uses thereof | 凯麦拉医疗公司 | 2022-09-13 | — | — | CN | disclosed |