Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23218869 | 1.00 | MAOB (0.38) | MAOBMAOAALDH1A1HTTPSMB8 | |
| SCHEMBL23218940 | 0.91 | KCNH2 (0.35) | MAOBMAOAALDH1A1HTTPSMB8 | |
| SCHEMBL29852664 | 0.91 | KCNH2 (0.35) | MAOBMAOAALDH1A1HTTPSMB8 | |
| SCHEMBL29852699 | 0.84 | MAOA (0.40) | MAOBMAOAALDH1A1HTTMAPT | |
| SCHEMBL23219080 | 0.84 | MAOA (0.40) | MAOBMAOAALDH1A1HTTMAPT | |
| SCHEMBL28736109 | 0.83 | CFD (0.44) | PSMB8PSMB5MAPTTP53KMT2A | |
| SCHEMBL29853127 | 0.83 | CFD (0.44) | PSMB8PSMB5MAPTTP53KMT2A | |
| SCHEMBL23218680 | 0.78 | THRB (0.41) | MAOBMAOAALDH1A1HTTMAPT | |
| SCHEMBL29853258 | 0.78 | THRB (0.41) | MAOBMAOAALDH1A1HTTMAPT | |
| SCHEMBL23218697 | 0.77 | MAPT (0.40) | MAOBMAOAALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041238-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-08-17 | — | — | EP | disclosed |