Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | USP14 | P54578 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29856251 | 0.85 | ELANE (0.41) | ELANESLC22A12HIPK2ROCK2ADORA3 | |
| SCHEMBL29856329 | 0.85 | ELANE (0.41) | ELANESLC22A12HIPK2ROCK2ADORA3 | |
| SCHEMBL29856198 | 0.85 | ELANE (0.41) | ELANESLC22A12HIPK2ROCK2ADORA3 | |
| SCHEMBL29856274 | 0.82 | ROCK2 (0.36) | ELANEHIPK2ROCK2ADORA3ADORA2A | |
| SCHEMBL29856218 | 0.78 | SLC22A12 (0.44) | ELANESLC22A12HIPK2ROCK2ADORA3 | |
| SCHEMBL29856309 | 0.78 | SLC22A12 (0.39) | ELANESLC22A12HIPK2ROCK2ADORA3 | |
| SCHEMBL29856150 | 0.74 | SLC22A12 (0.42) | ELANESLC22A12ROCK2ADORA3ADORA2A | |
| SCHEMBL29856491 | 0.74 | SLC22A12 (0.38) | SLC22A12ROCK2ADORA3ADORA2A | |
| SCHEMBL29856578 | 0.67 | ELANE (0.38) | ELANESLC22A12HIPK2ROCK2ADORA3 | |
| SCHEMBL29856503 | 0.65 | ADORA3 (0.44) | ROCK2ADORA3ADORA2AUSP14KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169974-A1 | INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF | NEXYS THERAPEUTICS, INC. (US) | 2022-08-11 | — | — | WO | disclosed |