Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29856309 | 0.84 | SLC22A12 (0.39) | ROCK2ADORA3ADORA2AHIPK2ELANE | |
| SCHEMBL29856218 | 0.84 | SLC22A12 (0.44) | ROCK2ADORA3ADORA2AHIPK2ELANE | |
| SCHEMBL29856503 | 0.82 | ADORA3 (0.44) | ROCK2ADORA3ADORA2AMAPTESR1 | |
| SCHEMBL29856201 | 0.82 | ELANE (0.43) | ROCK2ADORA3ADORA2AHIPK2ELANE | |
| SCHEMBL29856150 | 0.80 | SLC22A12 (0.42) | ROCK2ADORA3ADORA2AELANE | |
| SCHEMBL29856491 | 0.80 | SLC22A12 (0.38) | ROCK2ADORA3ADORA2A | |
| SCHEMBL29856329 | 0.79 | ELANE (0.41) | ROCK2ADORA3ADORA2AHIPK2ELANE | |
| SCHEMBL29856340 | 0.78 | ROCK2 (0.38) | ROCK2ADORA3ADORA2AELANEMAPT | |
| SCHEMBL29856214 | 0.78 | KDM5A (0.40) | ROCK2ADORA3ADORA2AMAPTESR1 | |
| SCHEMBL29856230 | 0.78 | ROCK2 (0.42) | ROCK2ADORA3ADORA2AMAPTESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169974-A1 | INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF | NEXYS THERAPEUTICS, INC. (US) | 2022-08-11 | — | — | WO | disclosed |