Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 8/20 | 0.38 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29856292 | 0.85 | SRD5A2 (0.46) | ALDH1A1KMT2AMAPT | |
| SCHEMBL29857005 | 0.84 | SLC22A12 (0.43) | ALDH1A1LMNASLC22A12EYA3KMT2A | |
| SCHEMBL29856234 | 0.74 | ALOX15 (0.40) | ALOX15NPSR1ALDH1A1LMNASLC22A12 | |
| SCHEMBL29856214 | 0.73 | KDM5A (0.40) | LMNASLC22A12EYA3MAPTHPGD | |
| SCHEMBL29856238 | 0.73 | SLC22A12 (0.43) | SLC22A12EYA3KMT2ACYP2C9 | |
| SCHEMBL29856346 | 0.73 | DYRK1A (0.34) | CYP3A4HPGD | |
| SCHEMBL29856217 | 0.71 | TUBB4A (0.41) | LMNASLC22A12EYA3MAPTHPGD | |
| SCHEMBL29856224 | 0.70 | LMNA (0.37) | ALOX15NPSR1ALDH1A1LMNASLC22A12 | |
| SCHEMBL29856237 | 0.70 | MAPT (0.40) | ALOX15NPSR1ALDH1A1LMNASLC22A12 | |
| SCHEMBL29856273 | 0.68 | COMT (0.40) | ALOX15NPSR1ALDH1A1LMNASLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169974-A1 | INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF | NEXYS THERAPEUTICS, INC. (US) | 2022-08-11 | — | — | WO | disclosed |