Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.34 |
| ▸ | CHRNG | P07510 | 1/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22061829 | 0.84 | DPP4 (0.36) | DPP4CYP11B2CYP19A1CYP11B1CYP17A1 | |
| SCHEMBL31140530 | 0.80 | MAPT (0.41) | DPP4CYP11B2CYP19A1CYP11B1CYP17A1 | |
| SCHEMBL22009927 | 0.79 | HTR6 (0.40) | DPP4CYP11B2CYP19A1CYP11B1CYP17A1 | |
| SCHEMBL29556433 | 0.79 | HTR6 (0.40) | DPP4CYP11B2CYP19A1CYP11B1CYP17A1 | |
| SCHEMBL122002 | 0.74 | CYP11B2 (0.43) | DPP4CYP11B2CYP19A1CYP11B1CYP17A1 | |
| SCHEMBL31160051 | 0.71 | CYP11B2 (0.45) | DPP4CYP11B2CYP19A1CYP11B1CYP17A1 | |
| SCHEMBL28458968 | 0.71 | CYP11B2 (0.45) | DPP4CYP11B2CYP19A1CYP11B1CYP17A1 | |
| SCHEMBL31192651 | 0.71 | DPP4 (0.44) | DPP4CYP11B2CYP19A1CYP11B1CYP17A1 | |
| SCHEMBL31192649 | 0.70 | DPP4 (0.38) | DPP4CYP11B2CYP19A1CYP11B1CYP17A1 | |
| SCHEMBL10501106 | 0.69 | CYP11B2 (0.39) | DPP4CYP11B2CYP19A1CYP11B1CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250099431-A1 | GLP-1R MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2025-03-27 | — | — | US | disclosed |
| US-12121511-B2 | GLP-1R modulating compounds | GILEAD SCIENCES, INC. (US) | 2024-10-22 | — | — | US | disclosed |
| US-20220288030-A1 | GLP-1R MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2022-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12121511-B2 | GLP-1R modulating compounds | GLP1R, GIPR, GPR119 | DPP4 18/4885CYP11B2 3375/4885CYP19A1 3231/4885 |
| US-20250099431-A1 | GLP-1R MODULATING COMPOUNDS | GLP1R, GIPR, GPR119 | DPP4 18/4885CYP11B2 3375/4885CYP19A1 3231/4885 |
| US-20220288030-A1 | GLP-1R MODULATING COMPOUNDS | GLP1R, GIPR, GPR119 | DPP4 18/4885CYP11B2 3375/4885CYP19A1 3231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.