Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29684443 | 0.79 | NOS1 (0.39) | NOS1HTTPTK2 | |
| SCHEMBL19661001 | 0.76 | HTT (0.44) | HTTPTK2SLC2A1 | |
| SCHEMBL4830696 | 0.76 | NOS1 (0.37) | NOS1HTTPTK2 | |
| SCHEMBL4838398 | 0.76 | NOS1 (0.37) | NOS1HTTPTK2 | |
| SCHEMBL24553744 | 0.76 | HTT (0.44) | NOS1HTTPTK2SLC2A1 | |
| SCHEMBL29864632 | 0.76 | NOS1 (0.34) | NOS1HTTPTK2 | |
| SCHEMBL22119097 | 0.72 | HTT (0.36) | NOS1HTTPTK2 | |
| SCHEMBL30774307 | 0.72 | HTT (0.36) | NOS1HTTPTK2 | |
| SCHEMBL25267720 | 0.68 | CLK1 (0.38) | NOS1 | |
| SCHEMBL30746075 | 0.68 | NOS1 (0.41) | NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4291559-A1 | PYRROLO[3,2-D]PYRIMIDINE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | Tango Therapeutics, Inc. (US) | 2023-12-20 | — | — | EP | disclosed |
| WO-2022174184-A1 | PYRROLO[3,2-D]PYRIMIDINE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | TANGO THERAPEUTICS, INC. (US) | 2022-08-18 | — | — | WO | disclosed |