Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
| ▸ | ATR | Q13535 | 3/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 2/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29864329 | 0.87 | ALDH1A1 (0.44) | YTHDC1ALDH1A1LMNAPOLBCYP4F2 | |
| SCHEMBL12398418 | 0.80 | YTHDC1 (0.47) | YTHDC1ALDH1A1LMNAPOLBCYP4F2 | |
| SCHEMBL23013670 | 0.77 | ALDH1A1 (0.42) | YTHDC1ALDH1A1LMNAPOLBCYP4F2 | |
| SCHEMBL19211047 | 0.76 | ALDH1A1 (0.44) | YTHDC1ALDH1A1LMNAPOLBCYP4F2 | |
| SCHEMBL31288076 | 0.75 | ALDH1A1 (0.43) | YTHDC1ALDH1A1LMNAPOLBCYP4F2 | |
| Hydrochloric Acid SCHEMBL23014449 | 0.74 | ALDH1A1 (0.40) | YTHDC1ALDH1A1LMNAPOLBCYP4F2 | |
| SCHEMBL23014451 | 0.73 | ALDH1A1 (0.39) | YTHDC1ALDH1A1LMNAPOLBCYP4F2 | |
| SCHEMBL24402225 | 0.72 | PDE4D (0.46) | YTHDC1ALDH1A1LMNAPOLBCYP4F2 | |
| SCHEMBL31144187 | 0.72 | PDE4D (0.46) | YTHDC1ALDH1A1LMNAPOLBCYP4F2 | |
| SCHEMBL28495548 | 0.72 | ALDH1A1 (0.42) | YTHDC1ALDH1A1LMNAPOLBCYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4291559-A1 | PYRROLO[3,2-D]PYRIMIDINE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | Tango Therapeutics, Inc. (US) | 2023-12-20 | — | — | EP | disclosed |
| WO-2022174184-A1 | PYRROLO[3,2-D]PYRIMIDINE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | TANGO THERAPEUTICS, INC. (US) | 2022-08-18 | — | — | WO | disclosed |