Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 5/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 5/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | PDE9A | O76083 | 1/20 | 0.30 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29863818 | 0.87 | YTHDC1 (0.42) | ALDH1A1LMNAPOLBYTHDC1RXRA | |
| SCHEMBL56169 | 0.78 | YTHDC1 (0.46) | ALDH1A1LMNAPOLBYTHDC1RXRA | |
| SCHEMBL19211047 | 0.78 | ALDH1A1 (0.44) | ALDH1A1LMNAPOLBYTHDC1RXRA | |
| SCHEMBL17200351 | 0.75 | ALDH1A1 (0.43) | ALDH1A1LMNAPOLBYTHDC1RXRA | |
| SCHEMBL17357047 | 0.74 | LMNA (0.48) | ALDH1A1LMNAPOLBYTHDC1RXRA | |
| SCHEMBL23013670 | 0.74 | ALDH1A1 (0.42) | ALDH1A1LMNAPOLBYTHDC1RXRA | |
| SCHEMBL28495548 | 0.74 | ALDH1A1 (0.42) | ALDH1A1LMNAPOLBYTHDC1RXRA | |
| SCHEMBL31358026 | 0.73 | ALDH1A1 (0.44) | ALDH1A1LMNAPOLBYTHDC1RXRA | |
| SCHEMBL29712045 | 0.73 | RXRA (0.47) | ALDH1A1LMNAPOLBYTHDC1RXRA | |
| SCHEMBL23013915 | 0.73 | ALDH1A1 (0.44) | ALDH1A1LMNAPOLBYTHDC1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024233605-A1 | COMPOUNDS AND THEIR USE AGAINST CANCER | TANGO THERAPEUTICS, INC. (US) | 2024-11-14 | — | — | WO | disclosed |
| EP-4313967-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2024-02-07 | — | — | EP | disclosed |
| EP-4291559-A1 | PYRROLO[3,2-D]PYRIMIDINE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | Tango Therapeutics, Inc. (US) | 2023-12-20 | — | — | EP | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |
| WO-2022174184-A1 | PYRROLO[3,2-D]PYRIMIDINE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | TANGO THERAPEUTICS, INC. (US) | 2022-08-18 | — | — | WO | disclosed |