Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | CTSG | P08311 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5844438 | 0.84 | SLC15A1 (0.36) | SMN1; SMN2L3MBTL1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL9845210 | 0.83 | ELANE (0.39) | ELANEMAPTSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL28606626 | 0.79 | KDM4E (0.36) | ELANEMAPTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL9799076 | 0.78 | TBXAS1 (0.36) | KMT2APRSS1 | |
| SCHEMBL15888456 | 0.76 | MAPK1 (0.37) | SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL30159093 | 0.75 | SMYD2 (0.35) | SMN1; SMN2ABL1 | |
| SCHEMBL6546547 | 0.75 | CYP2C19 (0.35) | MAPTSMN1; SMN2ALDH1A1KMT2AKDM4E | |
| SCHEMBL6072557 | 0.75 | ABL1 (0.35) | MAPTSMN1; SMN2TSHRPRSS1CTSG | |
| SCHEMBL26566724 | 0.74 | CYP3A4 (0.37) | MAPTSMN1; SMN2L3MBTL1CES2CES1 | |
| SCHEMBL13380801 | 0.74 | MAPT (0.50) | ELANEMAPTSMN1; SMN2L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3514158-B1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC (US) | 2022-10-12 | — | — | EP | disclosed |