Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | CTSG | P08311 | 2/20 | 0.34 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.34 |
| ▸ | CMA1 | P23946 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6546547 | 0.88 | CYP2C19 (0.35) | CYP2C19HIF1AMAPTSMN1; SMN2GAA | |
| SCHEMBL6072557 | 0.88 | ABL1 (0.35) | CYP2C19HIF1APRSS1CTSGCTRB1 | |
| SCHEMBL4644895 | 0.86 | TSHR (0.35) | CYP2C19HIF1AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL4647513 | 0.85 | CYP2C19 (0.33) | CYP2C19HIF1AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL4647641 | 0.85 | ALDH1A1 (0.36) | CYP2C19HIF1AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL6072563 | 0.85 | CYP2C19 (0.37) | CYP2C19HIF1APRSS1CTSGCTRB1 | |
| SCHEMBL6545076 | 0.85 | KDM4E (0.36) | CYP2C19HIF1AMAPTSMN1; SMN2GAA | |
| SCHEMBL30116362 | 0.84 | KDM4E (0.46) | CES2CES1L3MBTL1KDM4EMEN1 | |
| SCHEMBL6656947 | 0.83 | NR4A2 (0.38) | CYP2C19HIF1ASMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL4644661 | 0.83 | CYP2C19 (0.33) | CYP2C19HIF1AMAPTALDH1A1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3559007-A1 | SULFONAMIDE COMPOUNDS HAVING TNAP INHIBITORY ACTIVITY | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-10-30 | — | — | EP | disclosed |
| WO-2018119444-A1 | SULFONAMIDE COMPOUNDS HAVING TNAP INHIBITORY ACTIVITY | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-06-28 | — | — | WO | disclosed |
| EP-0462667-A2 | Beta-lactams as antihypercholesterolemics | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |