Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 4/20 | 0.64 |
| ▸ | CYP11B1 | P15538 | 12/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 12/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL480265 | 0.90 | ALOX5AP (0.80) | ALOX5APCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL3000550 | 0.86 | ALOX5AP (0.85) | ALOX5APCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL3001360 | 0.84 | ALOX5AP (0.61) | ALOX5APCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL3004289 | 0.79 | KIF11 (0.51) | ALOX5APCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL10198938 | 0.78 | ALOX5AP (0.79) | ALOX5APCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL480262 | 0.78 | ALOX5AP (0.82) | ALOX5APCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL9924164 | 0.78 | ALOX5AP (0.76) | ALOX5APCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL480275 | 0.78 | ALOX5AP (1.00) | ALOX5APCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL480286 | 0.78 | ALOX5AP (1.00) | ALOX5APCYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL480261 | 0.76 | ALOX5AP (0.75) | ALOX5APCYP11B1CYP11B2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2546232-A1 | Diphenyl Substituted Alkanes | Merck Sharp & Dohme Corp. (US) | 2013-01-16 | — | — | EP | disclosed |
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK SHARP & DOHME CORP. | 2010-07-29 | — | — | US | disclosed |
| EP-2170065-A1 | DIPHENYL SUBSTITUTED ALKANES | Merck Sharp & Dohme Corp. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008156721-A1 | DIPHENYL SUBSTITUTED ALKANES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190761-A1 | DIPHENYL SUBSTITUTED ALKANES | ALOX5, ALOX15, ALOX15B | ALOX5AP 15/4885CYP11B1 237/4885CYP11B2 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.