Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.34 |
| ▸ | ICMT | O60725 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29812644 | 0.76 | MAP2K1 (0.41) | TYRALDH1A1KDM4EMAP2K2MAP2K1 | |
| SCHEMBL843916 | 0.74 | CNR2 (0.64) | TYRCNR2 | |
| SCHEMBL843701 | 0.71 | CNR2 (0.63) | CNR2 | |
| SCHEMBL29811981 | 0.69 | POLB (0.39) | ALDH1A1ADRA1D | |
| SCHEMBL843837 | 0.68 | CNR2 (0.60) | TYRCNR2ALDH1A1 | |
| SCHEMBL15485807 | 0.68 | ALDH1A1 (0.47) | TYRCNR2ALDH1A1 | |
| SCHEMBL29812501 | 0.67 | ELANE (0.40) | CNR2ICMT | |
| SCHEMBL11557176 | 0.67 | ALDH1A1 (0.53) | TYRCNR2ALDH1A1KDM4E | |
| SCHEMBL28341822 | 0.66 | CCNC (0.47) | ALDH1A1KDM4EMAP2K2MAP2K1 | |
| SCHEMBL844095 | 0.66 | CNR2 (0.46) | TYRCNR2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4294804-A1 | PYRIDONE COMPOUNDS AND METHODS OF USE | Exelixis, Inc. (US) | 2023-12-27 | — | — | EP | claimed |
| WO-2022178205-A1 | PYRIDONE COMPOUNDS AND METHODS OF USE | EXELIXIS, INC. (US) | 2022-08-25 | — | — | WO | claimed |
| CN-117440951-A | Pyridone compounds and methods of use | 埃克塞里艾克西斯公司 | 2024-01-23 | — | — | CN | disclosed |
| EP-4294804-A1 | PYRIDONE COMPOUNDS AND METHODS OF USE | Exelixis, Inc. (US) | 2023-12-27 | — | — | EP | disclosed |
| WO-2022178205-A1 | PYRIDONE COMPOUNDS AND METHODS OF USE | EXELIXIS, INC. (US) | 2022-08-25 | — | — | WO | disclosed |