Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10460355 | 0.87 | TSHR (0.47) | TSHRLMNAPOLBKMT2AMEN1 | |
| SCHEMBL29812205 | 0.85 | LMNA (0.43) | LMNAGRIA2GRIA4CSNK1EMAPT | |
| SCHEMBL11429710 | 0.81 | LMNA (0.58) | TSHRLMNAKMT2AGAAGRIA2 | |
| SCHEMBL29868162 | 0.77 | POLB (0.41) | LMNAPOLBKMT2AALDH1A1SRC | |
| SCHEMBL30174249 | 0.77 | ALDH1A1 (0.43) | TSHRLMNAPOLBKMT2AMEN1 | |
| SCHEMBL30174300 | 0.77 | L3MBTL1 (0.39) | TSHRPOLBKMT2AMEN1MAPT | |
| SCHEMBL23146989 | 0.74 | LMNA (0.44) | TSHRLMNAKMT2AMEN1GRIA2 | |
| SCHEMBL10462656 | 0.74 | LMNA (0.44) | LMNAKMT2AGAAGRIA2GRIA4 | |
| SCHEMBL19815390 | 0.74 | HSD17B10 (0.49) | TSHRPOLBKMT2AMEN1GAA | |
| SCHEMBL10463742 | 0.74 | LMNA (0.44) | TSHRLMNAKMT2AMEN1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4294804-A1 | PYRIDONE COMPOUNDS AND METHODS OF USE | Exelixis, Inc. (US) | 2023-12-27 | — | — | EP | disclosed |
| WO-2022178205-A1 | PYRIDONE COMPOUNDS AND METHODS OF USE | EXELIXIS, INC. (US) | 2022-08-25 | — | — | WO | disclosed |