Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.51 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.51 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.50 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13888072 | 0.82 | TBK1 (0.53) | TGFBR1IKBKEPDPK1RPS6KA5TBK1 | |
| SCHEMBL12281270 | 0.79 | PDPK1 (0.48) | TGFBR1IKBKEPDPK1RPS6KA5TBK1 | |
| SCHEMBL858166 | 0.79 | MAP3K5 (0.54) | TGFBR1IKBKEPDPK1RPS6KA5TBK1 | |
| SCHEMBL1797960 | 0.77 | AXL (0.66) | GSK3BAXLCAMKK2CDK8 | |
| SCHEMBL5618155 | 0.77 | TGFBR1 (0.71) | TGFBR1IKBKEPDPK1RPS6KA5TBK1 | |
| SCHEMBL13521575 | 0.77 | DYRK1A (0.50) | TGFBR1IKBKEPDPK1RPS6KA5TBK1 | |
| SCHEMBL24672103 | 0.74 | ROCK1 (0.53) | IKBKEPDPK1RPS6KA5TBK1CDC7 | |
| SCHEMBL30668749 | 0.74 | TGFBR1 (0.51) | TGFBR1IKBKEPDPK1RPS6KA5TBK1 | |
| SCHEMBL2241248 | 0.74 | TGFBR1 (0.51) | TGFBR1IKBKEPDPK1RPS6KA5TBK1 | |
| SCHEMBL29870401 | 0.74 | CDC7 (0.60) | TGFBR1IKBKEPDPK1RPS6KA5TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11447505-B1 | Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2022-09-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447505-B1 | Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer | PDXK, CCNK, CDC42BPB | TGFBR1 4808/4885IKBKE 506/4885PDPK1 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.