Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 4/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23215013 | 1.00 | STS (0.42) | STSGPR119ALDH1A1TP53POLB | |
| SCHEMBL29886345 | 0.89 | GPR119 (0.44) | STSGPR119ALDH1A1MEN1KMT2A | |
| SCHEMBL29886059 | 0.89 | ALDH1A1 (0.42) | STSGPR119ALDH1A1TP53POLB | |
| SCHEMBL23215172 | 0.89 | ALDH1A1 (0.42) | STSGPR119ALDH1A1TP53POLB | |
| SCHEMBL23214924 | 0.89 | GPR119 (0.44) | STSGPR119ALDH1A1MEN1KMT2A | |
| SCHEMBL23216598 | 0.89 | LMNA (0.42) | STSGPR119ALDH1A1MEN1KMT2A | |
| SCHEMBL29885812 | 0.80 | PDK4 (0.44) | GPR119JAK1NAMPT | |
| SCHEMBL23216560 | 0.80 | PDK4 (0.44) | GPR119JAK1NAMPT | |
| SCHEMBL23216873 | 0.79 | LMNA (0.44) | MEN1KMT2ALMNASMN1; SMN2MAPT | |
| SCHEMBL29886227 | 0.79 | LMNA (0.44) | MEN1KMT2ALMNASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041407-A1 | ARYL HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D.E. Shaw Research, LLC (US) | 2022-08-17 | — | — | EP | disclosed |