Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 3/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29888844 | 0.81 | SLC6A4 (0.56) | CCR5SLC6A4SLC6A2SLC6A3KMT2A | |
| SCHEMBL3696560 | 0.81 | SLC6A4 (0.56) | CCR5SLC6A4SLC6A2SLC6A3KMT2A | |
| SCHEMBL1516692 | 0.79 | FBP1 (0.44) | SLC6A4KMT2ALMNASMN1; SMN2KDM4E | |
| SCHEMBL31053304 | 0.79 | FBP1 (0.44) | SLC6A4KMT2ALMNASMN1; SMN2KDM4E | |
| SCHEMBL29964333 | 0.79 | CCR5 (0.52) | CCR5SLC6A4SLC6A2SLC6A3KMT2A | |
| SCHEMBL29965019 | 0.76 | CCR5 (0.56) | CCR5SLC6A4SLC6A2SLC6A3KMT2A | |
| SCHEMBL425797 | 0.76 | FBP1 (0.48) | KMT2ASMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL858361 | 0.76 | FDPS (0.50) | KMT2ASMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL4573266 | 0.76 | KDM4E (0.58) | KMT2ALMNASMN1; SMN2KDM4ERAB9A | |
| SCHEMBL4641066 | 0.75 | KDM4E (0.48) | KMT2ALMNASMN1; SMN2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022171034-A1 | BICYCLIC COMPOUND AS HPK1 INHIBITOR AND APPLICATION THEREOF | 江苏先声药业有限公司 | 2022-08-18 | — | — | WO | disclosed |