Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | S100A4 | P26447 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19973035 | 1.00 | GPR3 (0.41) | GPR3HTR2APOLBHDAC3HDAC4 | |
| Toluene SCHEMBL28351667 | 0.87 | LMNA (0.44) | GPR3HTR2APOLBKMT2AACHE | |
| SCHEMBL6421466 | 0.78 | GPR3 (0.44) | GPR3HTR2APOLBHDAC3HDAC4 | |
| SCHEMBL29711937 | 0.74 | GPR3 (0.41) | GPR3HTR2APOLBHDAC3HDAC4 | |
| SCHEMBL1766205 | 0.74 | GPR3 (0.46) | GPR3HTR2APOLBHDAC3HDAC4 | |
| SCHEMBL1568290 | 0.74 | GPR3 (0.46) | GPR3HTR2APOLBHDAC3HDAC4 | |
| SCHEMBL224931 | 0.74 | GPR3 (0.41) | GPR3HTR2APOLBHDAC3HDAC4 | |
| SCHEMBL1766128 | 0.74 | GPR3 (0.41) | GPR3HTR2APOLBHDAC3HDAC4 | |
| SCHEMBL7421342 | 0.74 | GPR3 (0.41) | GPR3HTR2APOLBHDAC3HDAC4 | |
| SCHEMBL29196425 | 0.74 | GPR3 (0.41) | GPR3HTR2APOLBHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4294392-A1 | TARGETED BIFUNCTIONAL DEGRADERS AND METHODS USING SAME | Yale University, Inc. (US) | 2023-12-27 | — | — | EP | disclosed |
| WO-2022178428-A1 | TARGETED BIFUNCTIONAL DEGRADERS AND METHODS USING SAME | YALE UNIVERSITY (US) | 2022-08-25 | — | — | WO | disclosed |