Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TDO2 | P48775 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ACP1 | P24666 | 2/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | RUVBL1 | Q9Y265 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29892985 | 0.91 | KDM4E (0.49) | ADORA3SMN1; SMN2TDO2KDM4EALDH1A1 | |
| SCHEMBL29893288 | 0.86 | MLYCD (0.44) | ADORA3SMN1; SMN2TDO2KDM4EALDH1A1 | |
| SCHEMBL29893608 | 0.86 | TDO2 (0.49) | ADORA3SMN1; SMN2TDO2KDM4EALDH1A1 | |
| SCHEMBL29893836 | 0.84 | SCN9A (0.54) | TDO2NAMPT | |
| SCHEMBL27077334 | 0.82 | TDO2 (0.44) | TDO2MAPTESR1ESR2DHODH | |
| SCHEMBL27077387 | 0.82 | HDAC4 (0.48) | TDO2NAMPT | |
| SCHEMBL27077480 | 0.82 | HDAC4 (0.48) | TDO2NAMPT | |
| SCHEMBL29893138 | 0.82 | NAMPT (0.53) | MAPTNAMPT | |
| SCHEMBL29893121 | 0.81 | NAMPT (0.48) | MAPTNAMPT | |
| SCHEMBL29893384 | 0.81 | KDM4E (0.50) | SMN1; SMN2TDO2KDM4EALDH1A1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313308-A1 | TEAD INHIBITORS AND USES THEREOF | Cedilla Therapeutics, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022204452-A1 | TEAD INHIBITORS AND USES THEREOF | CEDILLA THERAPEUTICS, INC. (US) | 2022-09-29 | — | — | WO | disclosed |