SCHEMBL29894243

SCHEMBL29894243

COc1ccc(C(OC[C@@H](CNC(=O)OCCCCCCO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)OC(=O)C(Cl)Cl)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.34

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PLA2G2A P14555 2/20 0.34
PLA2G10 O15496 1/20 0.34
PLA2G1B P04054 1/20 0.34
PLA2G5 P39877 1/20 0.34
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
LMNA P02545 3/20 0.33
SLC6A1 P30531 2/20 0.33
SLC6A11 P48066 1/20 0.33
KMT2A Q03164 2/20 0.32
MEN1 O00255 1/20 0.32
KIF11 P52732 1/20 0.32
MAPT P10636 1/20 0.30
TP53 P04637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27082801 0.87 KMT2A (0.40) NPC1RAB9ASMN1; SMN2LMNASLC6A1
SCHEMBL27082804 0.87 KMT2A (0.40) NPC1RAB9ASMN1; SMN2LMNASLC6A1
SCHEMBL27082993 0.87 NPC1 (0.38) PLA2G2APLA2G10PLA2G1BPLA2G5NPC1
SCHEMBL27082995 0.87 NPC1 (0.38) PLA2G2APLA2G10PLA2G1BPLA2G5NPC1
SCHEMBL29894147 0.82 PLA2G2A (0.35) PLA2G2APLA2G10PLA2G1BPLA2G5NPC1
SCHEMBL27250464 0.77 NPC1 (0.31) PLA2G2APLA2G10PLA2G1BPLA2G5NPC1
SCHEMBL29142567 0.76 KIF11 (0.39) NPC1RAB9ASMN1; SMN2KMT2AMEN1
SCHEMBL27250454 0.75
SCHEMBL29142569 0.74 NPC1 (0.39) NPC1RAB9ASMN1; SMN2LMNASLC6A1
SCHEMBL27250521 0.73 KIF11 (0.43) NPC1RAB9ASLC6A1SLC6A11KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240209018-A1 UNIVERSAL LINKER REAGENTS FOR DNA SYNTHESIS GENSCRIPT USA INC. 2024-06-27 US disclosed
EP-4313984-A1 UNIVERSAL LINKER REAGENTS FOR DNA SYNTHESIS Genscript USA Inc. (US) 2024-02-07 EP disclosed
WO-2022204102-A1 UNIVERSAL LINKER REAGENTS FOR DNA SYNTHESIS GENSCRIPT USA INC. (US) 2022-09-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240209018-A1 UNIVERSAL LINKER REAGENTS FOR DNA SYNTHESIS RNGTT, DTYMK, UNG PLA2G2A 2201/4885PLA2G10 2465/4885PLA2G1B 2937/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.