Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 6/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29901725 | 0.82 | KDM4E (0.39) | ALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL28834792 | 0.80 | SIRT6 (0.42) | SIRT6HTTTDP1ALDH1A1MAPT | |
| SCHEMBL29267729 | 0.70 | SIRT6 (0.47) | SIRT6HTTTDP1ALDH1A1MAPT | |
| SCHEMBL28834777 | 0.69 | CNR2 (0.40) | SIRT6CYP2C9CYP2C19CYP3A4ALDH1A1 | |
| SCHEMBL4677098 | 0.68 | TDP1 (0.49) | SIRT6TDP1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL28834826 | 0.67 | SIRT6 (0.45) | SIRT6THRBHTTTDP1ALDH1A1 | |
| SCHEMBL2916543 | 0.65 | MAPT (0.54) | SIRT6HTTTDP1CYP2C9CYP2C19 | |
| SCHEMBL23578505 | 0.65 | KDM4E (0.47) | SIRT6THRBHTTTDP1ALDH1A1 | |
| SCHEMBL30184037 | 0.65 | KDM4E (0.47) | SIRT6THRBHTTTDP1ALDH1A1 | |
| SCHEMBL25624261 | 0.64 | SIRT6 (0.53) | SIRT6HTTTDP1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115028644-A | SOS1 inhibitor heterocyclic compounds | 首药控股(北京)股份有限公司 | 2022-09-09 | — | — | CN | disclosed |