SCHEMBL29902993

SCHEMBL29902993

CN(C)C(=O)c1ccc(F)c(Cl)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPBAR1 Q8TDU6 1/20 0.48
ERN1 O75460 2/20 0.48
MAOA P21397 1/20 0.47
MAOB P27338 1/20 0.47
ALDH1A1 P00352 3/20 0.46
TAS1R3 Q7RTX0 2/20 0.44
TAS1R1 Q7RTX1 2/20 0.44
TAS1R2 Q8TE23 2/20 0.44
MEN1 O00255 1/20 0.44
MAPT P10636 1/20 0.44
CASP3 P42574 1/20 0.44
KMT2A Q03164 1/20 0.44
SENP7 Q9BQF6 1/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
HPGD P15428 1/20 0.44
SLC6A2 P23975 1/20 0.44
SLC6A4 P31645 1/20 0.44
SLC6A3 Q01959 1/20 0.44
HSP90AA1 P07900 1/20 0.44
HSP90AB1 P08238 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1782199 1.00 GPBAR1 (0.48) GPBAR1ERN1MAOAMAOBALDH1A1
SCHEMBL22259607 0.86 ERN1 (0.57) ERN1ALDH1A1SMN1; SMN2HPGDTACR2
SCHEMBL31073591 0.83 MLYCD (0.48) GPBAR1MAOAMAOBALDH1A1TAS1R3
SCHEMBL1438344 0.83 MLYCD (0.48) GPBAR1MAOAMAOBALDH1A1TAS1R3
SCHEMBL2653855 0.82 CES2 (0.59) ERN1MAOAMAOBALDH1A1TAS1R3
SCHEMBL355700 0.79 HSP90AA1 (0.67) ERN1ALDH1A1SMN1; SMN2HPGDHSP90AA1
SCHEMBL91409 0.79 ERN1 (0.49) GPBAR1ERN1MAOAMAOBALDH1A1
SCHEMBL12599208 0.79 NPC1 (0.49) ALDH1A1MEN1KMT2ASMN1; SMN2HPGD
SCHEMBL3787476 0.79 ALDH1A1 (0.51) ALDH1A1MEN1MAPTKMT2ASMN1; SMN2
SCHEMBL19750356 0.79 TSHR (0.46) GPBAR1MAOAMAOBALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110167926-B Poly-ADP ribose polymerase (PARP) inhibitors 米托布里奇公司 2022-09-13 CN disclosed