Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2995782 | 0.90 | CASP3 (0.45) | KMT2AMEN1KAT2BMAPTALDH1A1 | |
| SCHEMBL28908599 | 0.83 | KMT2A (0.70) | KMT2AHSD17B10MEN1MAPTALDH1A1 | |
| SCHEMBL11514616 | 0.80 | TSHR (0.52) | KMT2AHSD17B10MEN1KAT2BMAPT | |
| SCHEMBL9847185 | 0.77 | HDAC8 (0.67) | KMT2AHSD17B10MEN1MAPTALDH1A1 | |
| SCHEMBL7542052 | 0.77 | HDAC8 (0.67) | KMT2AHSD17B10MEN1MAPTALDH1A1 | |
| SCHEMBL7548208 | 0.77 | HDAC8 (0.67) | KMT2AHSD17B10MEN1MAPTALDH1A1 | |
| SCHEMBL7548687 | 0.77 | HDAC8 (0.67) | KMT2AHSD17B10MEN1MAPTALDH1A1 | |
| SCHEMBL8779372 | 0.77 | HDAC8 (0.67) | KMT2AHSD17B10MEN1MAPTALDH1A1 | |
| SCHEMBL7542107 | 0.77 | HDAC8 (0.67) | KMT2AHSD17B10MEN1MAPTALDH1A1 | |
| SCHEMBL29263645 | 0.77 | HDAC8 (0.67) | KMT2AHSD17B10MEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466191-B2 | Pyrroline derivatives against cell releasing tumor necrosis factor, preparation methods and uses thereof | ZHANG HESHENG (CN) | 2013-06-18 | — | — | US | disclosed |
| US-20100179189-A1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | ZHANG HESHENG | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179189-A1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | TNF, IL1B, NOS1 | KMT2A 4801/4885HSD17B10 3185/4885MEN1 642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.