Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852520 | 0.67 | ALDH1A1 (0.61) | ALDH1A1LMNAL3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL10242357 | 0.66 | ALDH1A1 (0.36) | ALDH1A1LMNATSHRSMN1; SMN2CHRM3 | |
| SCHEMBL23975594 | 0.64 | ALDH1A1 (0.59) | ALDH1A1TSHRSMN1; SMN2HSD17B10MAPK1 | |
| SCHEMBL14479660 | 0.64 | ALDH1A1 (0.59) | ALDH1A1TSHRSMN1; SMN2HSD17B10MAPK1 | |
| SCHEMBL19758232 | 0.61 | CRHBP (0.44) | ALDH1A1LMNAL3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL11982534 | 0.61 | DPP4 (0.49) | ALDH1A1LMNASMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL12240392 | 0.61 | SMN1; SMN2 (0.46) | ALDH1A1LMNAL3MBTL1SMN1; SMN2CHRM3 | |
| SCHEMBL21875351 | 0.61 | ALDH1A1 (0.45) | ALDH1A1LMNAL3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL5375112 | 0.60 | PDE10A (0.42) | ALDH1A1LMNAL3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL17979711 | 0.60 | CHRM3 (0.49) | ALDH1A1LMNAL3MBTL1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12043623-B2 | Purinones as ubiquitin-specific protease 1 inhibitors | FORMA THERAPEUTICS, INC. (US) | 2024-07-23 | — | — | US | disclosed |
| US-20220281869-A1 | PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS | FORMA THERAPEUTICS, INC. | 2022-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220281869-A1 | PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS | USP1, UBA1, UBXN1 | ALDH1A1 633/4885LMNA 2181/4885L3MBTL1 1816/4885 |
| US-12043623-B2 | Purinones as ubiquitin-specific protease 1 inhibitors | USP1, UBA1, UBXN1 | ALDH1A1 633/4885LMNA 2181/4885L3MBTL1 1816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.