Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29905556 | 0.80 | TTBK1 (0.48) | MKNK1EGFRFGFR2KDRFGFR1 | |
| SCHEMBL29905534 | 0.77 | BRD4 (0.46) | PDPK1LCKMAPTGAAKDR | |
| SCHEMBL15345676 | 0.74 | FGFR2 (0.47) | FGFR2KDRFGFR1FGFR4FGFR3 | |
| SCHEMBL30898398 | 0.70 | GRM5 (0.38) | EGFRALDH1A1FGFR2KDRFGFR1 | |
| SCHEMBL29724141 | 0.70 | GRM5 (0.38) | EGFRALDH1A1FGFR2KDRFGFR1 | |
| SCHEMBL29724135 | 0.70 | CHRNB2 (0.39) | EGFRALDH1A1FGFR2KDRFGFR1 | |
| SCHEMBL674040 | 0.69 | ALDH1A1 (0.65) | MAPTGAAALDH1A1 | |
| SCHEMBL29993245 | 0.69 | XDH (0.55) | PDPK1MKNK1RETPI4KAXDH | |
| SCHEMBL29724132 | 0.68 | GRM5 (0.38) | EGFRFGFR2FGFR4FGFR3 | |
| SCHEMBL29724130 | 0.68 | FGFR2 (0.48) | FGFR2KDRFGFR1FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115043832-B | FGFR inhibitor acetylenic heterocyclic compound and preparation method and application thereof | 药雅科技(上海)有限公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-115043832-A | FGFR inhibitor alkyne-substituted heterocyclic compound and preparation method and application thereof | 药雅科技(上海)有限公司 | 2022-09-13 | — | — | CN | disclosed |