Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 10/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4585799 | 0.83 | ADORA2A (0.75) | ADORA2AADORA1BRD4CREBBPADORA2B | |
| SCHEMBL29907731 | 0.80 | ADORA2A (0.52) | ADORA2AADORA1ADORA2BCNR1ADORA3 | |
| SCHEMBL29907757 | 0.80 | ADORA2A (0.48) | ADORA2AADORA1BRD4ADORA2BCNR1 | |
| SCHEMBL29907672 | 0.80 | ADORA2A (0.51) | ADORA2AADORA1BRD4ADORA2B | |
| SCHEMBL4585557 | 0.80 | ADORA2A (0.65) | ADORA2AADORA1BRD4CREBBPADORA2B | |
| SCHEMBL29907681 | 0.79 | ADORA2A (0.48) | ADORA2AADORA1BRD4CREBBPADORA2B | |
| SCHEMBL29907708 | 0.78 | TGFBR1 (0.51) | ADORA2AADORA1TGFBR1TGFBR2 | |
| SCHEMBL29906682 | 0.77 | ADORA2A (0.47) | ADORA2AADORA1ADORA2BTGFBR1TGFBR2 | |
| SCHEMBL29907763 | 0.77 | ADORA2A (0.47) | ADORA2AADORA1ADORA2BTGFBR1TGFBR2 | |
| SCHEMBL29987316 | 0.75 | ADORA2A (0.65) | ADORA2AADORA1BRD4CREBBPADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |