Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 14/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29907659 | 0.79 | ADORA2A (0.56) | ADORA2AADORA1ADORA2BBRD4CREBBP | |
| SCHEMBL29907672 | 0.77 | ADORA2A (0.51) | ADORA2ADYRK1AADORA1ADORA2BBRD4 | |
| SCHEMBL29907757 | 0.75 | ADORA2A (0.48) | ADORA2ADYRK1AADORA1ADORA2BBRD4 | |
| SCHEMBL27646771 | 0.70 | ADORA2A (0.45) | ADORA2ADYRK1AADORA1ADORA2BBRD4 | |
| SCHEMBL29907714 | 0.69 | ADORA2A (0.51) | ADORA2ADYRK1AADORA1ADORA2BBRD4 | |
| SCHEMBL30828878 | 0.68 | TGFBR1 (0.44) | ADORA2ADYRK1AADORA1ADORA2BBRD4 | |
| SCHEMBL30845797 | 0.67 | TGFBR1 (0.48) | DYRK1ABRD4CREBBP | |
| SCHEMBL4585704 | 0.67 | ADORA2A (0.46) | ADORA2ADYRK1AADORA1ADORA2BBRD4 | |
| SCHEMBL21722349 | 0.66 | ADORA2A (1.00) | ADORA2AADORA1ADORA2B | |
| SCHEMBL4583598 | 0.66 | ADORA2A (0.55) | ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |