Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.34 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.33 |
| ▸ | CHKA | P35790 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.32 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3054197 | 0.79 | TRPV4 (0.43) | TRPV4AR | |
| SCHEMBL11012305 | 0.77 | GRM4 (0.34) | ARPLA2G7ALDH1A1GRM4CNR2 | |
| SCHEMBL3165753 | 0.77 | TRPV4 (0.39) | TRPV4KDM4EARMEN1MAPT | |
| SCHEMBL29907686 | 0.77 | TRPV4 (0.39) | TRPV4KDM4EARMEN1MAPT | |
| SCHEMBL3050947 | 0.76 | AR (0.49) | AR | |
| SCHEMBL3060332 | 0.76 | VCAM1 (0.40) | KDM4EMAPTKMT2AALDH1A1HPGD | |
| SCHEMBL3051509 | 0.73 | VCAM1 (0.50) | KDM4EMAPTKMT2AALDH1A1HPGD | |
| SCHEMBL2515805 | 0.73 | CHKA (0.40) | CHKAKDM4EMEN1MAPTKMT2A | |
| SCHEMBL2656097 | 0.72 | XDH (0.43) | TRPV4PTP4A3KDM4EARMEN1 | |
| SCHEMBL6153135 | 0.71 | KCNA5 (0.40) | CHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |