Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA3 | O75311 | 1/20 | 0.45 |
| ▸ | GLRB | P48167 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.35 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.34 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 2/20 | 0.33 |
| ▸ | GABRD | O14764 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12248226 | 1.00 | GLRA3 (0.45) | GLRA3GLRBMAPK1CFTRBACE1 | |
| SCHEMBL29907677 | 0.81 | KDM4E (0.40) | BACE1KDM4EL3MBTL1KDM6BKDM5C | |
| SCHEMBL29906724 | 0.80 | SIRT6 (0.44) | GLRA3GLRBCFTRBACE1LCK | |
| SCHEMBL68869 | 0.76 | MAPK1 (0.63) | MAPK1KDM4EL3MBTL1LCKPCSK9 | |
| SCHEMBL30114679 | 0.74 | GLRA3 (0.46) | GLRA3GLRBMAPK1CFTRMAPK8 | |
| SCHEMBL15896819 | 0.74 | GLRA3 (0.56) | GLRA3GLRBMAPK1CFTRKDM4E | |
| SCHEMBL6467515 | 0.73 | KDM4E (0.49) | GLRA3GLRBMAPK1CFTRKDM4E | |
| SCHEMBL3971624 | 0.73 | ALDH1A1 (0.45) | MAPK1KDM4EL3MBTL1ALDH1A1MAPT | |
| SCHEMBL30163064 | 0.73 | KDM4E (0.63) | GLRA3GLRBCFTRKDM4EL3MBTL1 | |
| SCHEMBL29218201 | 0.73 | KDM4E (0.63) | GLRA3GLRBCFTRKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |