Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | ASPH | Q12797 | 3/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.35 |
| ▸ | P4HA1 | P13674 | 3/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM6B | O15054 | 1/20 | 0.34 |
| ▸ | TET3 | O43151 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.34 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29906724 | 0.88 | SIRT6 (0.44) | BACE1HPGDSALDH1A1HDAC4GSK3B | |
| SCHEMBL29907727 | 0.81 | GLRA3 (0.45) | KDM4EBACE1ALDH1A1KDM6BMAPT | |
| SCHEMBL12248226 | 0.81 | GLRA3 (0.45) | KDM4EBACE1ALDH1A1KDM6BMAPT | |
| SCHEMBL2436714 | 0.72 | ALDH1A1 (0.36) | KDM4EHPGDSASPHKDM8ALDH1A1 | |
| Iodide SCHEMBL7459681 | 0.72 | KDM4E (0.54) | KDM4ENAPRTHCAR2ASPHKDM8 | |
| SCHEMBL70035 | 0.72 | KDM4E (0.59) | KDM4ENAPRTHCAR2ASPHKDM8 | |
| SCHEMBL7940958 | 0.71 | HPGDS (0.37) | BACE1HPGDSLTA4H | |
| SCHEMBL15896821 | 0.70 | KDM4E (0.52) | KDM4ENAPRTHCAR2HPGDSASPH | |
| Water SCHEMBL6129699 | 0.70 | KDM4E (0.52) | KDM4ENAPRTHCAR2ASPHKDM8 | |
| SCHEMBL7767700 | 0.70 | KDM4E (0.56) | KDM4ENAPRTHCAR2ASPHKDM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |