Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 11/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | TERT | O14746 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15211555 | 1.00 | KDM4E (0.46) | KDM4EALDH1A1SIRT2CHRM5CHKA | |
| SCHEMBL28603232 | 0.85 | HRH1 (0.46) | KDM4EALDH1A1SIRT2CHRM5CHKA | |
| SCHEMBL9480589 | 0.82 | KDM4E (0.47) | KDM4EALDH1A1SIRT2CHRM5CHKA | |
| SCHEMBL11616152 | 0.81 | SIRT2 (0.45) | KDM4EALDH1A1SIRT2TERTLOXL2 | |
| SCHEMBL4308808 | 0.80 | ALDH1A1 (0.50) | KDM4EALDH1A1SIRT2CHRM5CHKA | |
| SCHEMBL31182983 | 0.80 | KDM4E (0.46) | KDM4EALDH1A1SIRT2CHRM5CHKA | |
| SCHEMBL7664616 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1SIRT2CHRM5CHKA | |
| SCHEMBL4307694 | 0.80 | KDM4E (0.46) | KDM4EALDH1A1SIRT2CHRM5CHKA | |
| SCHEMBL15212887 | 0.80 | KDM4E (0.46) | KDM4EALDH1A1SIRT2CHRM5CHKA | |
| SCHEMBL17993855 | 0.79 | MEN1 (0.41) | ALDH1A1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |