SCHEMBL29909207

SCHEMBL29909207

Cc1nnc2nc(N3CCOc4c(Br)cccc43)c3cc(F)ccc3n12

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PIK3CA P42336 2/20 0.32
PIK3CB P42338 2/20 0.32
PIK3CG P48736 2/20 0.32
PTAFR P25105 1/20 0.31
DGAT1 O75907 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23576677 1.00 PIK3CA (0.32) PIK3CAPIK3CBPIK3CGPTAFRDGAT1
SCHEMBL23601548 0.91 PIK3CD (0.35) PIK3CAPIK3CBPIK3CGPTAFR
SCHEMBL23601077 0.86 DHODH (0.33) PTAFR
SCHEMBL30047169 0.85 DHODH (0.32)
SCHEMBL30047539 0.85 PER2 (0.30) PTAFR
SCHEMBL24813167 0.85 PER2 (0.30) PTAFR
SCHEMBL29909342 0.83 DHODH (0.36) PTAFR
SCHEMBL23577938 0.83 MAPT (0.33) PIK3CAPIK3CBPIK3CG
SCHEMBL23576692 0.83 DHODH (0.36) PTAFR
SCHEMBL29909214 0.83 MAPT (0.33) PIK3CAPIK3CBPIK3CG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118324767-A Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2024-07-12 CN disclosed
EP-4081305-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2022-11-02 EP disclosed