Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 3/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.33 |
| ▸ | FEN1 | P39748 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 4/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | CSF1R | P07333 | 2/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29909148 | 0.90 | DHODH (0.39) | ABCG2DHODHPDE2ATDP1DHFR | |
| SCHEMBL29909252 | 0.82 | ABCG2 (0.45) | ABCG2DHODH | |
| SCHEMBL29909783 | 0.82 | DHODH (0.37) | ABCG2DHODHNR3C1PGR | |
| SCHEMBL29909452 | 0.81 | DHODH (0.38) | ABCG2DHODH | |
| SCHEMBL29909078 | 0.80 | PTGDR2 (0.37) | ABCG2DHODHNR3C1 | |
| SCHEMBL29909024 | 0.79 | ABCG2 (0.37) | ABCG2DHODHPDE2ADHFREGFR | |
| SCHEMBL29909871 | 0.79 | ABCG2 (0.40) | ABCG2DHODHCSF1R | |
| SCHEMBL23601022 | 0.78 | HSD11B1 (0.37) | ABCG2HSD11B1GRM2ALOX5APFEN1 | |
| SCHEMBL30960977 | 0.78 | HSD11B1 (0.37) | ABCG2HSD11B1GRM2ALOX5APFEN1 | |
| SCHEMBL29909909 | 0.78 | DHODH (0.41) | ABCG2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4081305-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | Carna Biosciences, Inc. (JP) | 2022-11-02 | — | — | EP | disclosed |