SCHEMBL29909567

SCHEMBL29909567

CCN(c1cccc(Br)c1)c1nc2nncn2c2cc(Cl)ccc12

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAT2A P31153 6/20 0.36
PRMT5 O14744 2/20 0.36
CYP1A2 P05177 1/20 0.36
MAPT P10636 4/20 0.36
TP53 P04637 3/20 0.35
FNTA P49354 1/20 0.34
FNTB P49356 1/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
POLB P06746 1/20 0.34
CYP3A4 P08684 1/20 0.34
HRH4 Q9H3N8 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
HTT P42858 1/20 0.33
KMT2A Q03164 1/20 0.33
HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23577387 1.00 MAT2A (0.36) MAT2APRMT5CYP1A2MAPTTP53
SCHEMBL29909162 0.87 PDGFRB (0.38) MAT2APRMT5CYP1A2FNTAFNTB
SCHEMBL23577196 0.87 PDGFRB (0.38) MAT2APRMT5CYP1A2FNTAFNTB
SCHEMBL29909555 0.87 MAPT (0.32) MAT2APRMT5CYP1A2MAPTTP53
SCHEMBL23577594 0.87 MAPT (0.32) MAT2APRMT5CYP1A2MAPTTP53
SCHEMBL23577663 0.84 ALOX15 (0.36) MAPTTP53SMN1; SMN2KDM4EHPGD
SCHEMBL30961039 0.84 ALOX15 (0.36) MAPTTP53SMN1; SMN2KDM4EHPGD
SCHEMBL24807021 0.83 MAPT (0.36) MAPTTP53
SCHEMBL23601451 0.82 RORC (0.41) MAT2APRMT5CYP1A2
SCHEMBL23577465 0.80 PTGES (0.35) MAT2APRMT5CYP1A2MAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118324767-A Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2024-07-12 CN disclosed
EP-4081305-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2022-11-02 EP disclosed