SCHEMBL29909658

SCHEMBL29909658

CN(c1cc(F)cc(Br)c1)c1nc2nncn2c2cc(C#N)ccc12

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
NCEH1 Q6PIU2 1/20 0.32
ABCG2 Q9UNQ0 1/20 0.31
CYP19A1 P11511 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23577271 1.00 NCEH1 (0.32) NCEH1ABCG2CYP19A1
SCHEMBL23576693 0.85 MAT2A (0.35)
SCHEMBL29909100 0.85 MAT2A (0.35)
SCHEMBL23576946 0.84
SCHEMBL23576663 0.83 KIF11 (0.30)
SCHEMBL29909628 0.83 KIF11 (0.30)
SCHEMBL23601193 0.82 ABCG2 (0.44) ABCG2
SCHEMBL30013722 0.82 CSNK2A1 (0.36) ABCG2
SCHEMBL23577324 0.81 MAPT (0.33) ABCG2
SCHEMBL29909815 0.81 MAPT (0.33) ABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118324767-A Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2024-07-12 CN disclosed
CN-115362003-A Diacylglycerol kinase modulating compounds 卡尔那生物科学株式会社 2022-11-18 CN disclosed
EP-4081305-A1 DIACYLGLYCEROL KINASE MODULATING COMPOUNDS Carna Biosciences, Inc. (JP) 2022-11-02 EP disclosed