Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29913465 | 0.82 | CHRM2 (0.47) | ACHEDRD2DRD4DRD3HTR3E | |
| SCHEMBL29913682 | 0.81 | NPY1R (0.36) | LMNADRD2HTR1AHTR2CHTR3A | |
| SCHEMBL27228599 | 0.78 | ACHE (0.50) | ACHE | |
| SCHEMBL27228273 | 0.75 | SIGMAR1 (0.53) | LMNADRD2DRD4DRD3SMN1; SMN2 | |
| SCHEMBL29913506 | 0.74 | HTR3E (0.39) | LMNACYP2D6HTR3EHTR3BHTR1A | |
| SCHEMBL29913468 | 0.74 | GAA (0.36) | ACHELMNAHTR1A | |
| SCHEMBL29913676 | 0.72 | KDM4E (0.45) | ACHECYP3A4CYP2D6DRD2DRD4 | |
| SCHEMBL28081867 | 0.71 | KDM4E (0.42) | ALDH1A1TP53CYP3A4 | |
| SCHEMBL27228365 | 0.70 | CYP2D6 (0.44) | ALDH1A1LMNACYP3A4CYP2D6HPGD | |
| SCHEMBL29913679 | 0.70 | CHRM2 (0.50) | ACHEALDH1A1CYP2D6DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4305029-A1 | NEW 2,3-DIHYDRO-1H-PYRROLO[3,2-B]PYRIDINE DERIVATIVES AS SIGMA LIGANDS | Acondicionamiento Tarrasense (ES) | 2024-01-17 | — | — | EP | disclosed |
| WO-2022189392-A1 | NEW 2,3-DIHYDRO-1H-PYRROLO[3,2-b]PYRIDINE DERIVATIVES AS SIGMA LIGANDS | ACONDICIONAMIENTO TARRASENSE (ES) | 2022-09-15 | — | — | WO | disclosed |