Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952138 | 0.88 | CHEK1 (0.49) | MEN1KMT2AGAALMNASMN1; SMN2 | |
| SCHEMBL29915854 | 0.88 | CHEK1 (0.49) | MEN1KMT2AGAALMNASMN1; SMN2 | |
| SCHEMBL14154058 | 0.86 | CHEK1 (0.50) | MEN1KMT2AGAALMNASMN1; SMN2 | |
| SCHEMBL17583584 | 0.85 | MEN1 (0.45) | MEN1KMT2AGAALMNASMN1; SMN2 | |
| SCHEMBL17583585 | 0.85 | GABRP (0.44) | MEN1KMT2AGAALMNASMN1; SMN2 | |
| SCHEMBL23959045 | 0.85 | RAB9A (0.46) | MEN1KMT2AGAALMNASMN1; SMN2 | |
| SCHEMBL23959070 | 0.85 | MEN1 (0.44) | MEN1KMT2AGAALMNASMN1; SMN2 | |
| SCHEMBL28735590 | 0.85 | MEN1 (0.46) | MEN1KMT2AGAALMNASMN1; SMN2 | |
| SCHEMBL23959055 | 0.83 | RAB9A (0.51) | GAASMN1; SMN2TTRMAPTRAB9A | |
| SCHEMBL17583578 | 0.80 | SCN9A (0.44) | MEN1KMT2AGAALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112824384-B | Propargylated 3, 3-disubstituted indoline-2-ketone compound containing continuous chiral center and synthesis method thereof | 中国科学院大连化学物理研究所 | 2022-09-16 | — | — | CN | disclosed |