Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 3/20 | 0.53 |
| ▸ | CNR1 | P21554 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2982729 | 0.87 | CNR1 (0.51) | ALDH1A1GAAKDM4EMEN1KMT2A | |
| SCHEMBL2987865 | 0.84 | KLK7 (0.55) | ALDH1A1GAAKDM4EMEN1KMT2A | |
| SCHEMBL2993999 | 0.81 | KMT2A (0.57) | ALDH1A1GAAKDM4EMEN1KMT2A | |
| SCHEMBL10969548 | 0.79 | RORB (0.60) | ALDH1A1KDM4EKMT2ASMN1; SMN2LMNA | |
| SCHEMBL2992641 | 0.77 | SLC6A12 (0.55) | ALDH1A1GAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2992551 | 0.77 | KMT2A (0.50) | ALDH1A1GAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7745858 | 0.77 | ALDH1A1 (0.57) | ALDH1A1GAAKDM4EMEN1KMT2A | |
| SCHEMBL12709415 | 0.77 | P2RX7 (0.61) | ALDH1A1GAAKDM4EMEN1KMT2A | |
| SCHEMBL31583752 | 0.77 | P2RX7 (0.58) | ALDH1A1GAAKDM4EMEN1KMT2A | |
| SCHEMBL2071080 | 0.77 | MAP4K4 (0.47) | ALDH1A1GAAKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173888-A1 | Nicotinamide Derivatives | PFIZER INC | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173888-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | ALDH1A1 172/4885GAA 887/4885KDM4E 3753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.