Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21138821 | 0.73 | DGAT1 (0.42) | PDE10ADGAT1EGLN2MKNK1 | |
| SCHEMBL30537 | 0.73 | DGAT1 (0.42) | PDE10ADGAT1EGLN2MKNK1 | |
| SCHEMBL9911039 | 0.72 | DGAT1 (0.34) | PDE10ADGAT1 | |
| SCHEMBL14158421 | 0.68 | DYRK1A (0.40) | PDE10ADGAT1 | |
| SCHEMBL20484514 | 0.68 | DGAT1 (0.36) | PDE10ADGAT1 | |
| SCHEMBL17781090 | 0.68 | KDM4E (0.39) | DGAT1EGLN2 | |
| SCHEMBL1236763 | 0.66 | AKT1 (0.46) | DGAT1EGLN2 | |
| SCHEMBL11165302 | 0.65 | FYN (0.44) | DGAT1EGLN2MKNK1 | |
| SCHEMBL31579411 | 0.65 | IDO1 (0.46) | DGAT1 | |
| SCHEMBL31579398 | 0.65 | IDO1 (0.46) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051963-B1 | PROCESS FOR RESOLVING CHIRAL PIPERIDINE ALCOHOL AND PROCESS FOR SYNTHESIS OF PYRAZOLO [1,5-A]PYRIMIDINE DERIVATIVES USING SAME | SCHERING CORP (US) | 2012-05-16 | — | — | EP | claimed |
| US-8076479-B2 | useful as cyclin-dependent kinase inhibitor compounds; minimizes the need for chromatographic purification of intermediates, and utilizes fewer changes of solvent systems | SCHERING CORPORATION (US) | 2011-12-13 | — | — | US | claimed |
| US-7786306-B2 | Process for resolving chiral piperidine alcohol and process for synthesis of pyrazolo[1,5-a] pyrimidine derivatives using same | SCHERING CORPORATION (US) | 2010-08-31 | — | — | US | claimed |
| EP-2057166-A2 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF (3-ALKYL-5-PIPERIDIN-1-YL-3,3A-DIHYDRO- PYRAZOLOÝ1,5-A¨PYRIMIDIN-7-YL)-AMINO DERIVATIVES AND INTERMEDIATES | SCHERING CORPORATION (US) | 2009-05-13 | — | — | EP | claimed |
| EP-2051963-A1 | PROCESS FOR RESOLVING CHIRAL PIPERIDINE ALCOHOL AND PROCESS FOR SYNTHESIS OF PYRAZOLO [1,5-A]PYRIMIDINE DERIVATIVES USING SAME | SCHERING CORPORATION (US) | 2009-04-29 | — | — | EP | claimed |
| WO-2008027220-A2 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF (3-ALKYL-5-PIPERIDIN-1-YL-3, 3A-DIHYDROPYRAZOL0 [1, 5-A] PYRIMIDIN-7-YL) -AMINO DERIVATIVES | SCHERING CORPORATION (US) | 2008-03-06 | — | — | WO | claimed |
| US-20080058518-A1 | Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives and intermediates | MERCK SHARP & DOHME LLC | 2008-03-06 | — | — | US | claimed |
| US-20080051579-A1 | Process for resolving chiral piperidine alcohol and process for synthesis of pyrazolo[1,5-a] pyrimidine derivatives using same | MERCK SHARP & DOHME LLC | 2008-02-28 | — | — | US | claimed |
| WO-2008021509-A1 | PROCESS FOR RESOLVING CHIRAL PIPERIDINE ALCOHOL AND PROCESS FOR SYNTHESIS OF PYRAZOLO [1,5-A] PYRIMIDINE DERIVATIVES USING SAME | SCHERING CORPORATION (US) | 2008-02-21 | — | — | WO | claimed |
| EP-2051963-B1 | PROCESS FOR RESOLVING CHIRAL PIPERIDINE ALCOHOL AND PROCESS FOR SYNTHESIS OF PYRAZOLO [1,5-A]PYRIMIDINE DERIVATIVES USING SAME | SCHERING CORP (US) | 2012-05-16 | — | — | EP | disclosed |
| US-7786306-B2 | Process for resolving chiral piperidine alcohol and process for synthesis of pyrazolo[1,5-a] pyrimidine derivatives using same | SCHERING CORPORATION (US) | 2010-08-31 | — | — | US | disclosed |
| EP-2051963-A1 | PROCESS FOR RESOLVING CHIRAL PIPERIDINE ALCOHOL AND PROCESS FOR SYNTHESIS OF PYRAZOLO [1,5-A]PYRIMIDINE DERIVATIVES USING SAME | SCHERING CORPORATION (US) | 2009-04-29 | — | — | EP | disclosed |
| US-20080051579-A1 | Process for resolving chiral piperidine alcohol and process for synthesis of pyrazolo[1,5-a] pyrimidine derivatives using same | MERCK SHARP & DOHME LLC | 2008-02-28 | — | — | US | disclosed |
| WO-2008021509-A1 | PROCESS FOR RESOLVING CHIRAL PIPERIDINE ALCOHOL AND PROCESS FOR SYNTHESIS OF PYRAZOLO [1,5-A] PYRIMIDINE DERIVATIVES USING SAME | SCHERING CORPORATION (US) | 2008-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051579-A1 | Process for resolving chiral piperidine alcohol and process for synthesis of pyrazolo[1,5-a] pyrimidine derivatives using same | ADH1C, ADH1A, ADH5 | PDE10A 3020/4885DGAT1 612/4885EGLN2 3933/4885 |
| US-20080058518-A1 | Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives and intermediates | CDK3, CDK7, CDK2 | PDE10A 2467/4885DGAT1 3448/4885EGLN2 1194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.