Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | VEGFA | P15692 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14656203 | 1.00 | SOS1 (0.40) | SOS1MAOBHTR2ASLC6A4MAOA | |
| SCHEMBL14656303 | 0.85 | SOS1 (0.44) | SOS1MAOBHTR2ASLC6A4THRB | |
| SCHEMBL14667731 | 0.85 | HTR2A (0.42) | MAOBHTR2ASLC6A4MAOATHRB | |
| SCHEMBL14656099 | 0.85 | THRB (0.44) | HTR2ASLC6A4THRBRORC | |
| SCHEMBL15903973 | 0.84 | THRB (0.40) | MAOBHTR2ASLC6A4MAOATHRB | |
| SCHEMBL14656049 | 0.84 | LTA4H (0.41) | SOS1MAOBTHRBRORCLTA4H | |
| SCHEMBL14656137 | 0.82 | KIF11 (0.53) | — | |
| SCHEMBL14656157 | 0.82 | PLA2G7 (0.44) | HTR2ASLC6A4 | |
| SCHEMBL5125208 | 0.81 | LTA4H (0.57) | SOS1MAOBHTR2ASLC6A4MAOA | |
| SCHEMBL18235868 | 0.81 | HSP90AA1 (0.45) | HTR2ASLC6A4THRBRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4056571-A1 | TRICYCLIC DIHYDROIMIDAZOPYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Simr Biotechnology Co., Ltd. (CN) | 2022-09-14 | — | — | EP | disclosed |