Sugi Predict

Sugi Predict / Compounds / SCHEMBL29919552

SCHEMBL29919552

SCHEMBL29919552

O=C1c2ccccc2C(=O)N1C[C@@H](O)Cc1ccc(OCc2ccccc2)cc1

nearest known ligand 0.62

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 1/20 0.62
▸ KMT2A Q03164 2/20 0.56
▸ PPARG P37231 3/20 0.52
▸ PPARA Q07869 3/20 0.52
▸ LTA4H P09960 3/20 0.49
▸ LAP3 P28838 1/20 0.49
▸ FFAR1 O14842 1/20 0.48
▸ FFAR4 Q5NUL3 1/20 0.48
▸ PPARD Q03181 1/20 0.47
▸ GRM5 P41594 2/20 0.47
▸ RAB9A P51151 2/20 0.47
▸ TSHR P16473 1/20 0.46
▸ HSD17B10 Q99714 1/20 0.46
▸ AMY1A P0DUB6 1/20 0.46
▸ PTPN1 P18031 1/20 0.46
▸ DPP4 P27487 1/20 0.46
▸ GSTP1 P09211 1/20 0.46
▸ POLB P06746 1/20 0.46
▸ MAOB P27338 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25152979 1.00 MAPK1 (0.62) MAPK1KMT2APPARGPPARALTA4H
SCHEMBL27086721 1.00 MAPK1 (0.62) MAPK1KMT2APPARGPPARALTA4H
SCHEMBL4784138 0.86 MAPK1 (0.66) MAPK1KMT2ARAB9APOLB
SCHEMBL29919477 0.82 KMT2A (0.48) MAPK1KMT2APPARGPPARALTA4H
SCHEMBL27086811 0.82 KMT2A (0.48) MAPK1KMT2APPARGPPARALTA4H
SCHEMBL25152984 0.82 KMT2A (0.48) MAPK1KMT2APPARGPPARALTA4H
SCHEMBL29162584 0.81 MAPK1 (0.51) MAPK1KMT2APPARGPPARARAB9A
SCHEMBL29162583 0.81 MAPK1 (0.51) MAPK1KMT2APPARGPPARARAB9A
SCHEMBL30726156 0.81 MAPK1 (0.51) MAPK1KMT2APPARGPPARARAB9A
SCHEMBL1680623 0.79 CASP3 (0.61) GRM5PTPN1GSTP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12168648-B2 Opioid receptor modulators EPIODYNE, INC. (US) 2024-12-17 — — US disclosed
US-20240092746-A1 OPIOID RECEPTOR MODULATORS EPIODYNE, INC. 2024-03-21 — — US disclosed
EP-4320105-A1 OPIOID RECEPTOR MODULATORS Epiodyne, Inc. (US) 2024-02-14 — — EP disclosed
CN-117425644-A Opioid receptor modulators 埃皮欧黛公司 2024-01-19 — — CN disclosed
US-11634396-B2 Opioid receptor modulators EPIODYNE, INC. (US) 2023-04-25 — — US disclosed
US-20220356157-A1 OPIOID RECEPTOR MODULATORS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-11-10 — — US disclosed
WO-2022216750-A1 OPIOID RECEPTOR MODULATORS EPIODYNE, INC. (US) 2022-10-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240092746-A1 OPIOID RECEPTOR MODULATORS OPRM1, OPRK1, OPRL1 MAPK1 3001/4885KMT2A 3195/4885PPARG 395/4885
US-12168648-B2 Opioid receptor modulators OPRM1, OPRK1, OPRL1 MAPK1 3001/4885KMT2A 3195/4885PPARG 395/4885
US-11634396-B2 Opioid receptor modulators OPRM1, OPRK1, OPRL1 MAPK1 3001/4885KMT2A 3195/4885PPARG 395/4885
US-20220356157-A1 OPIOID RECEPTOR MODULATORS OPRM1, OPRK1, OPRL1 MAPK1 3001/4885KMT2A 3195/4885PPARG 395/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.