SCHEMBL299222

SCHEMBL299222

CCc1cc(C(F)(C(F)(F)F)C(F)(F)C(F)(F)F)cc(Br)c1NC(=O)c1ccc(C#N)cc1

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MLYCD O95822 3/20 0.41
RXFP1 Q9HBX9 2/20 0.38
EPHX2 P34913 1/20 0.38
ALDH1A1 P00352 3/20 0.37
PKM P14618 1/20 0.37
MEN1 O00255 2/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
KMT2A Q03164 2/20 0.36
ESR1 P03372 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
LMNA P02545 1/20 0.36
GPR35 Q9HC97 1/20 0.35
KDM4E B2RXH2 1/20 0.35
MAP3K5 Q99683 1/20 0.35
POLB P06746 1/20 0.34
TRPV1 Q8NER1 1/20 0.34
GFER P55789 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3225084 0.86 KCNQ3 (0.40)
SCHEMBL3213487 0.85 KDM4E (0.34) ALDH1A1KDM4E
SCHEMBL299549 0.85 MLYCD (0.43) MLYCDRXFP1ALDH1A1PKMMEN1
SCHEMBL1275272 0.84 MLYCD (0.45) MLYCDRXFP1EPHX2ALDH1A1PKM
SCHEMBL3708470 0.84 RXFP1 (0.34) RXFP1ALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL3201501 0.82 LMNA (0.41) ALDH1A1MEN1NPC1RAB9AKMT2A
SCHEMBL1766884 0.82 RXFP1 (0.49) MLYCDRXFP1MEN1NPC1RAB9A
SCHEMBL18355407 0.81 RXFP1 (0.45) MLYCDRXFP1ALDH1A1MEN1KMT2A
SCHEMBL17178374 0.81 MLYCD (0.48) MLYCDRXFP1ALDH1A1MEN1NPC1
SCHEMBL3226993 0.80 KDM4E (0.36) ALDH1A1NPC1RAB9AKDM4EMAP3K5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2427427-A1 4 -CYANO- 3 -BENZOYLAMINO-N- PHENYL-BENZAMIDES FOR USE IN PEST CONTROL Syngenta Participations AG (CH) 2012-03-14 EP disclosed